After being bitten by a spider, Peter Parker reflects on the brief normalcy in his life before chaos ensues. A botched spell to make everyone forget he is Spider-Man opens portals to other universes, bringing villains like Dr. Otto Octavius into his world. These visitors must be sent back as they face their fates of dying while fighting Spider-Man in their respective realities. Struggling with guilt and responsibility, Peter realizes there may not be another way out as the multiverse begins collapsing further.