Treatment of autoimmune diseases without drugs. Vitamin C, fasting and exercise.

Understanding Autoimmune Diseases Autoimmune diseases occur when the immune system attacks our own cells and tissues, leading to various debilitating conditions such as type 1 diabetes, rheumatoid arthritis, Crohn's disease, and multiple sclerosis. The current understanding suggests that these diseases develop due to a lack of activation or insufficient quantity of regulatory T-cells during the formation of the immune system.

Causes and Development of Autoimmune Diseases The development of autoimmune diseases is attributed to genetic defects or congenital damage in genes responsible for producing regulatory T-cells. For example, type 1 diabetes develops in newborns due to a genetic defect related to the production of Foxp3 protein which determines the functioning of regulatory T-cells.

Epigenetic Regulation and T-Cell Function The nucleus of human cells contains a system that switches genes on and off, affecting the function of T regulatory cells. In people with autoimmune diseases, genes encoding FoxP3 protein are inadequately activated due to genetic control mechanisms. Epigenetic mechanisms play a key role in this process by controlling gene expression through DNA methylation and demethylation.

Impact on Autoimmune Diseases Late-onset autoimmune diseases like adult latent autoimmune diabetes result from genetic regulation failures where certain genes are not activated properly, leading to an imbalance in immune responses. Surface molecules on T regulatory cells receive signals from cytokines like interleukin 2, activating enzymes that mimic DNA and regulate gene expression through methylation (addition) or demethylation (removal) of methyl groups at specific sites.

Epigenetic factors can influence the development and activity of autoimmune diseases by regulating the production of Foxp3 protein. Factors that lead to increased genetic regulation of Foxp3 production may trigger autoimmune diseases, while those that stimulate Foxp3 protein formation may inhibit autoimmunity.

Vitamin C activates T regulatory cells, leading to enhanced immune response.

Regulating Autoimmune Reactions Intermittent fasting, keto diet, and physical exercise can increase the production of FoxP3 protein, leading to a decrease in autoimmune reactions.

Influencing Cell Activity Blocking the system ADR1 leads to tumor development and autoimmune diseases. Increasing 1-ZMP levels in cells can reduce M31 activity through activation of DNA kinase-activating protein kinase. Prolonged physical exercise or fasting results in negative energy balance, reducing interluekin-1 (IL-1) activity and increasing T-regulatory cell function.

Consuming adequate vitamin C and engaging in regular aerobic exercises such as running or swimming may block IL-1 complex effectively without needing intermittent fasting for individuals who are physically active. However, intermittent fasting is beneficial for those with low physical activity levels.

To alleviate the course of autoimmune diseases, it is necessary to create an energy deficit. Even though the diet ultimately creates an energy deficit, it can help improve the condition of people with autoimmune diseases. Consuming sufficient vitamin C, practicing intermittent fasting or engaging in high volumes of physical exercise that create an energy deficit can provide relief for individuals with autoimmune conditions.