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Which is better: Soap or hand sanitizer? - Alex Rosenthal and Pall Thordarson

Molecular Disruption: Shattering Viral Envelopes Viruses like COVID-19 rely on a lipid bilayer held together by the hydrophobic effect, making them vulnerable to disruption. Soap molecules, acting as amphiphiles, wedge into this envelope to break up its orderly structure and form bubbles that encapsulate the virus’s components, which water then washes away. In contrast, alcohol-based sanitizers remove the hydrophobic effect, causing the viral membrane and spike proteins to collapse rapidly and rendering the virus inactive within seconds.

Thorough Hygiene and Adaptive Responses in Outbreaks Hand disinfection requires meticulous coverage of every crease for at least 20 seconds to ensure all pathogens are removed. Soap and water not only dismantle viral structures but also wash away dirt that may harbor lingering particles, whereas hand sanitizers offer a convenient alternative in the absence of a sink. For viruses with a robust protein capsid, sanitizer can be more effective, and innovative solutions like devices that produce chlorinated water highlight efforts to overcome limited water access, underscoring the need to follow accredited medical guidance.